Delayed recanalization in acute ischemic stroke patients: Late is better than never?
Jinwei PangArne P NeyrinckYong JiangPublished in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2019)
Successful recanalization of the occluded vessel as early as possible has been widely accepted as the key principle of acute ischemic stroke (AIS) treatment. Unfortunately, for many years, the vast majority of AIS patients were prevented from receiving effective recanalization therapy because of a narrow therapeutic window. Recently, a series of inspiring clinical trials have indicated that more patients may benefit from delayed recanalization during an expanded therapeutic window, even up to 24 h after symptom onset. However, could potentially salvageable brain tissue (penumbra) in patients who do not receive medication within 24 h still possible to be saved?
Keyphrases
- end stage renal disease
- acute ischemic stroke
- clinical trial
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- middle cerebral artery
- peritoneal dialysis
- randomized controlled trial
- endovascular treatment
- intensive care unit
- patient reported outcomes
- liver failure
- bone marrow
- brain injury
- electronic health record
- study protocol
- drug induced
- smoking cessation
- mechanical ventilation
- chemotherapy induced