Two decades after the International Dyslexia Association (IDA) adopted the 2002 consensus definition of dyslexia, this special issue of the Annals of Dyslexia revisits that definition in light of advances in scientific understanding and evolving needs. Through contributions from leading researchers and interdisciplinary teams, the issue examines the strengths and limitations of the definition as it has been applied in research, policy, and practice. Key themes emerged, which included reconsidering the need to include the neurobiological basis of dyslexia in the definition, the intersection of literacy challenges and mental health, and the role of context in shaping how dyslexia is defined. Contributors to this special issue also reflected on how the definition serves different audiences, including educators, policymakers, and families. As the IDA embarks on a thoughtful reassessment of the 2002 definition, this collection of articles offers insights to guide the path forward, ensuring the definition remains a robust tool for research, identification, intervention, and advocacy in the coming years.