Phosphate Restriction Prevents Metabolic Acidosis and Curbs Rise in FGF23 and Mortality in Murine Folic Acid-Induced AKI.

This study reveals Pi-sensitive FGF23 expression in bone but not in thymus or spleen in FA-AKI and demonstrates that Pi restriction mitigates CPP formation, inflammation, acidosis, and mortality in this model. These results suggest that dietary Pi restriction could have prophylactic potential in patients at risk for AKI.