The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer.
Hiroyuki AraiAndrew ElliottJoanne XiuJingyuan WangFrancesca BattaglinNatsuko KawanishiShivani SoniWu ZhangJoshua MillsteinDavendra SohalRichard M GoldbergMichael J HallAaron J ScottMoh'd M KhushmanJimmy J HwangEmil LouBenjamin A WeinbergJohn L MarshallAlbert C LockhartPhillip StaffordJian ZhangRoberto MorettoChiara CremoliniWolfgang Michael KornHeinz-Josef LenzPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We characterized a distinct subgroup of patients with colorectal cancer with tumors harboring mutations in the DDR-related genes. These patients more commonly had MSI-H tumors and exhibited an activated immune signature regardless of their tumor's MSI status. These findings warrant further investigations to develop personalized treatment strategies in this significant subgroup of patients with colorectal cancer.