Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks.
Sriram SundaravelWen-Liang KuoJong Jin JeongGaurav S ChoudharyShanisha Gordon-MitchellHui LiuTushar D BhagatKathy L McGrawSandeep GurbuxaniAlan F ListAmit VermaAmittha WickremaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
LYN kinase and phosphatases SHP1 and SHIP1 are perturbed when DOCK4 expression levels are low. Inhibition of SHP1 promotes erythroid differentiation in healthy HSCs and in -7/(del)7q MDS samples with low DOCK4 expression. Inhibitors of LYN, SHP1 and SHIP1 also abrogated increased migratory properties in HSCs expressing reduced levels of DOCK4.