Isolated cognitive impairment in people with multiple sclerosis: frequency, MRI patterns and its development over time.
Piet M BoumanMaureen A van DamLaura E JonkmanMartijn D SteenwijkMenno M SchoonheimJeroen J G GeurtsHanneke E HulstPublished in: Journal of neurology (2024)
Isolated cognitive impairment is frequently present in PwMS and can serve as a proxy for further decline, particularly when it concerns processing speed. Cortical and deep grey matter atrophy seem to play a pivotal role in isolated cognitive impairment. Timely detection and patient-tailored intervention, predominantly for IPS, may help to postpone further cognitive decline.
Keyphrases
- cognitive impairment
- cognitive decline
- multiple sclerosis
- mild cognitive impairment
- randomized controlled trial
- magnetic resonance imaging
- white matter
- case report
- contrast enhanced
- magnetic resonance
- computed tomography
- smoking cessation
- loop mediated isothermal amplification
- real time pcr
- diffusion weighted imaging
- sensitive detection