Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial.
Naoki InuiTakahito SuzukiKazuki TanakaMasato KarayamaYusuke InoueKazutaka MoriHideki YasuiHironao HozumiYuzo SuzukiKazuki FuruhashiTomoyuki FujisawaShun MatsuuraKoji NishimotoTakashi MatsuiKazuhiro AsadaDai HashimotoMasato FujiiMitsuru NiwaMasahiro UeharaHiroyuki MatsudaKeigo KodaMasaki IkedaNao InamiYutaro TamiyaMasato KatoHideki NakanoYasuaki MinoNoriyuki EnomotoTakafumi SudaPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
The addition of olanzapine was not associated with a significant increase in the overall CR rate. Regarding the prevention of nausea, adding olanzapine provided better control in patients receiving carboplatin-containing chemotherapy, which needs further exploration.