Glucagon-like peptide-2 acutely enhances chylomicron secretion in humans without mobilizing cytoplasmic lipid droplets.
Majid Mufaqam Syed-AbdulPriska StahelAlyssa S ZembroskiLili TianChangting XiaoAvital NahmiasIan BookmanKimberly K BuhmanGary Franklin LewisPublished in: The Journal of clinical endocrinology and metabolism (2022)
Unlike glucose that mobilizes enterocyte CLDs and enhances CM secretion, GLP-2 acutely increased plasma CMs without significant mobilization of CLDs, supporting our previous findings that GLP-2 does not act directly on enterocytes to enhance CM secretion and most likely mobilizes secreted CMs in the lamina propria and lymphatics.