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The lymphatic filariasis treatment study landscape: A systematic review of study characteristics and the case for an individual participant data platform.

Luzia T FreitasMashroor Ahmad KhanAzhar UddinJulia B HalderSauman Singh-PhulgendaJeyapal Dinesh RajaVijayakumar BalakrishnanEli HarrissManju RahiMatthew BrackPhilippe J GuérinMaria-Gloria BasáñezAshwani KumarMartin WalkerAdinarayanan Srividya
Published in: PLoS neglected tropical diseases (2024)
The LF treatment study landscape is heterogeneous, but the abundance of studies and related IPD suggest that establishing a global data repository to facilitate IPD meta-analyses would be feasible and useful to address unresolved questions on variation in treatment outcomes across geographies, demographics and in underrepresented groups. New studies using more standardized approaches should be initiated to address the scarcity and inconsistency of data on morbidity management.
Keyphrases
  • electronic health record
  • systematic review
  • big data
  • randomized controlled trial
  • lymph node
  • single cell
  • high throughput
  • machine learning
  • artificial intelligence
  • data analysis
  • microbial community