Installation of -SO2F groups onto primary amides.
Jing LiuShi-Meng WangNjud S AlharbiHua-Li QinPublished in: Beilstein journal of organic chemistry (2019)
A protocol of SO2F2-mediated installation of sulfonyl fluoride onto primary amides has been developed providing a new portal to sulfur(VI) fluoride exchange (SuFEx) click chemistry. The generated molecules contain pharmaceutically important amide and -SO2F moieties for application in the discovery of new therapeutics.