Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension.
Xiaofei ZhouYuanqing JiangYuewen WangLinge FanYunhui ZhuYefeng ChenYiran WangYingyi ZhuHongkun WangZihang PanZhoubin LiXiaolong ZhuRuizhe RenZhen GeDongwu LaiEn-Yin LaiTing ChenKai WangPing LiangLingfeng QinCuiqing LiuCong QiuMichael SimonsLuyang YuPublished in: Circulation research (2023)
By maintaining endothelial mitochondrial homeostasis, deSUMOylation of FIS1 adaptively preserves pulmonary endothelial function against hypoxic stress and consequently protects against PH. The FIS1 deSUMOylation-SUMOylation transition in pulmonary endothelium is an intrinsic pathogenesis of hypoxic PH.