Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca2+-ATPase Expression in Cardiomyocytes.

Mortimer Korf-Klingebiel Marc R Reboll Felix PoltenNatalie WeberFelix Jäckle Xuekun Wu Marinos KallikourdisPaolo KunderfrancoGianluigi CondorelliEvangelos GiannitsisOlga S KustikovaAxel SchambachAndreas PichJulian D WidderJohann Bauersachs Joop van den HeuvelTheresia KraftYong Wang Kai C Wollert

Published in: Circulation (2021)

These findings establish a MYDGF-based adaptive crosstalk between inflammatory cells and cardiomyocytes that protects against pressure overload-induced heart failure.

Keyphrases

endoplasmic reticulum
heart failure
growth factor
high glucose
diabetic rats
endothelial cells
induced apoptosis
poor prognosis
oxidative stress
left ventricular
drug induced
acute myeloid leukemia
bone marrow
acute heart failure
immune response
cardiac resynchronization therapy
cell death
long non coding rna