Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury.
Noam BosakPaulo BrancoPora KupermanChen BuxbaumRuth Manor CohenShiri FadelRabab ZubeidatRafi HadadAmir LawenNoam Saadon-GrosmanMichele SterlingYelena GranovskyApkar Vania ApkarianDavid YarnitskyItamar KahnPublished in: Annals of neurology (2022)
FC features obtained shortly after mTBI predict its transition to long-term chronic pain, and may reflect an underlying interaction of injury-related primary sensorimotor cortical areas with the mesolimbic and pain modulation systems. Our findings indicate a potential predictive biomarker and highlight targets for future early preventive interventions. ANN NEUROL 2022;92:819-833.
Keyphrases
- chronic pain
- mild traumatic brain injury
- resting state
- functional connectivity
- white matter
- pain management
- liver failure
- drug induced
- physical activity
- current status
- aortic dissection
- neural network
- multiple sclerosis
- hepatitis b virus
- climate change
- intensive care unit
- risk assessment
- brain injury
- neuropathic pain