Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.

Alexandra Coomans de BrachèneMaria Ines AlvelosFlorian Szymczak Priscila L ZimathAngela CastelaBianca Marmontel de SouzaArturo Roca RivadaSandra Marín-CañasXiaoyan YiAnne Op de BeeckNoel G MorganSebastian SonntagSayro JawurekAlexandra C TitleBurcak YesildagFrançois PattouJulie Kerr-ConteEduard MontanyaMontserrat NacherLorella MarselliPiero MarchettiSarah J RichardsonDecio L Eizirik

Published in: Diabetologia (2024)

These data suggest that IFN-α and IFN-γ are key cytokines at the islet level in human type 1 diabetes, contributing to the triggering and amplification of autoimmunity.

Keyphrases

artificial intelligence
type diabetes
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machine learning
deep learning
dendritic cells
glycemic control
immune response
endothelial cells
cardiovascular disease
insulin resistance
induced pluripotent stem cells
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adipose tissue
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