Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis.

Xiaofan LuYujie ZhouJialin MengLiyun JiangJun GaoXiaole FanYanfeng ChenYu ChengYang WangBing ZhangHangyu YanFangrong Yan

Published in: Clinical epigenetics (2020)

DNAm age is an independent predictor of CSCC prognosis. Better prognosis, overexpression of HPV E6/E7 oncoproteins, and higher enrichment of immune signatures were observed in DNAmAge-ACC tumours.

Keyphrases

squamous cell carcinoma
poor prognosis
gene expression
cell proliferation
high grade
binding protein
locally advanced
nk cells
cervical cancer screening