Metabolomics-Based Effects of a Natural Product on Remyelination After Cerebral Ischemia Injury Via GABABR-pCREB-BDNF Pathway.
Xiaodi FanMin ZhanWenting SongMingjiang YaoGuangrui WangTian LiYehao ZhangJianxun LiuPublished in: Neurorehabilitation and neural repair (2024)
YQTLs enhance the binding of GABA to GABABR, thereby activating the pCREB/BDNF signaling pathway, which in turn increases the expression of downstream myelin-associated proteins and promotes remyelination and cognitive function.
Keyphrases
- cerebral ischemia
- signaling pathway
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- poor prognosis
- stress induced
- pi k akt
- binding protein
- mass spectrometry
- epithelial mesenchymal transition
- induced apoptosis
- fluorescent probe
- living cells
- sensitive detection
- white matter
- dna binding
- long non coding rna
- oxidative stress
- multiple sclerosis
- transcription factor
- single molecule
- endoplasmic reticulum stress