Methyl-β-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide (LPS) or oxidized low-density lipoprotein (oxLDL).
Guo ChenYun ZhouWendiao ZhangYing QinBo WeiYanan SunYong ChenPublished in: Pharmaceutical biology (2021)
MβCD significantly suppresses the LPS/oxLDL-triggered monocyte-endothelial adhesion by downregulating adhesion molecule expression probably via LPS-IKK-NF-κB or oxLDL-Akt-NF-κB pathway. This study demonstrates a potential mechanism of the anti-atherosclerotic efficacy of cyclodextrin from the angle of monocyte-endothelial adhesion.
Keyphrases
- signaling pathway
- endothelial cells
- inflammatory response
- low density lipoprotein
- lps induced
- dendritic cells
- biofilm formation
- anti inflammatory
- pi k akt
- peripheral blood
- cell migration
- poor prognosis
- oxidative stress
- toll like receptor
- cell proliferation
- ionic liquid
- staphylococcus aureus
- immune response
- escherichia coli
- binding protein
- cell adhesion
- risk assessment
- climate change
- long non coding rna
- nk cells