Maternal supplementation with n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows.
Priscila Dos Santos SilvaGitit KraYana ButenkoJayasimha Rayalu DaddamYishai LevinMaya ZachutPublished in: Journal of animal science and biotechnology (2024)
Maternal n-3 FA from FLX and FO differentially affected the bovine placenta; both enhanced lipid metabolism and modulated oxidative stress, however, FO increased some transcriptional ECS components, possibly related to the increased FABPs. Maternal FO induced a unique balance of pro- and anti-inflammatory components in the placenta. Taken together, different sources of n-3 FA during late pregnancy enhanced placental immune and metabolic processes, which may affect the neonatal immune system.
Keyphrases
- oxidative stress
- pregnancy outcomes
- diabetic rats
- fatty acid
- dairy cows
- anti inflammatory
- birth weight
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- gene expression
- pregnant women
- high glucose
- preterm birth
- weight gain
- gestational age
- drug induced
- transcription factor
- signaling pathway
- endothelial cells
- heat shock protein