Involvement of CYP1B1 in interferon γ-induced alterations of epithelial barrier integrity.

Mireille AlhouayekSandra Gouveia-FigueiraMarie-Louise HammarströmChristopher John Fowler

Published in: British journal of pharmacology (2018)

These data suggest that increased expression of CYP1B1 is involved in the effects of IFNγ on epithelial permeability. Inhibition of CYP1B1 counteracts the alterations of epithelial barrier integrity induced by IFNγ and could thus have a therapeutic potential in disorders of intestinal permeability associated with inflammation.

Keyphrases

dendritic cells
immune response
poor prognosis
endothelial cells
oxidative stress
diabetic rats
big data
drug induced
long non coding rna
deep learning
artificial intelligence