Down-regulation of transient receptor potential melastatin member 7 prevents migration and invasion of renal cell carcinoma cells via inactivation of the Src and Akt pathway.
Yun-Sok HaYeon-Yong KimNa Hee YuSo Young ChunSeock Hwan ChoiJun Nyung LeeBum Soo KimEun Sang YooTae Gyun KwonPublished in: Investigative and clinical urology (2018)
Our data show that TRPM7 regulated ACHN and SN12C RCC cell invasion via the Src/Akt signaling pathway. Therefore, targeting the Src/Akt signaling pathway and/or the expression or function of TRPM7 could be a potential beneficial treatment for patients with RCC.
Keyphrases
- signaling pathway
- tyrosine kinase
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- renal cell carcinoma
- cell proliferation
- poor prognosis
- single cell
- human health
- electronic health record
- binding protein
- stem cells
- mesenchymal stem cells
- combination therapy
- climate change
- subarachnoid hemorrhage
- data analysis