CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer.

Chenlu ZhangZhi LiLing XuXiaofang CheTi WenYibo FanCe LiShuo WangYu ChengXiaoxun WangXiujuan QuYunpeng Liu

Published in: BMC cancer (2018)

CXCL9/10/11-CXCR3 upregulated the expression of PD-L1 by activating the STAT and PI3K-Akt signaling pathways in GC cells. There was a significant positive correlation between the expression of PD-L1 and CXCR3 in gastric cancer patient tissues.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
induced apoptosis
poor prognosis
cell proliferation
cell death
epithelial mesenchymal transition
gene expression
binding protein
cell migration
case report
long non coding rna
oxidative stress
gas chromatography