Radiosynthesis and preclinical evaluation of [ 11 C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging.
Romy CoolsKoen VermeulenValeria NarykinaRenan C F LeitaoGuy BormansPublished in: EJNMMI radiopharmacy and chemistry (2023)
C]SNX-ab is not an ideal probe for in vivo visualization and quantification of Hsp90α/β expression levels in tumour and brain. Future research in the development of next-generation Hsp90 isoform-selective PET tracers is warranted to dissect the role played by each isoform towards disease pathology and support the development of subtype-specific Hsp90 therapeutics.
Keyphrases
- heat shock protein
- heat shock
- heat stress
- pet imaging
- white matter
- computed tomography
- resting state
- pet ct
- positron emission tomography
- poor prognosis
- high resolution
- quantum dots
- living cells
- small molecule
- oxidative stress
- long non coding rna
- cerebral ischemia
- mass spectrometry
- mesenchymal stem cells
- fluorescent probe