INPP4B overexpression and c-KIT downregulation in human achalasia.

E BonoraF BiancoA StanzaniF GiancolaA AstolfiV IndioC EvangelistiA M MartelliE BoschettiM LugaresiA IoannouF TorresanV StanghelliniP ClavenzaniM SeriA MoonenK Van BeekM WoutersG E BoeckxstaensG ZaninottoS MattioliRoberto De Giorgio

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

The identification of altered gene expression, including INPP4B, a regulator of the Akt pathway, highlights novel signaling pathways involved in the neuronal and ICC changes underlying primary achalasia.

Keyphrases

signaling pathway
gene expression
cell proliferation
endothelial cells
pi k akt
transcription factor
dna methylation
epithelial mesenchymal transition
induced pluripotent stem cells
induced apoptosis
pluripotent stem cells
bioinformatics analysis
brain injury