Fractional flow reserve-guided PCI as compared with coronary bypass surgery (FAME III)- another brick in the wall!
Pradeep NarayanPublished in: Indian journal of thoracic and cardiovascular surgery (2022)
FAME III, a multi-centric randomized controlled trial compared fractional flow reserve (FFR) guided percutaneous coronary interventions (PCI) with coronary artery bypass grafting. The study confirmed that compared with FFR-guided-PCI, coronary artery bypass grafting was associated with a significantly lower incidence of the composite of mortality, stroke, MI, and repeat revascularizations at 1 year. Thus, FFR-guided-PCI failed to meet the "noninferiority" criteria.
Keyphrases
- coronary artery bypass grafting
- coronary artery disease
- percutaneous coronary intervention
- cardiovascular events
- st segment elevation myocardial infarction
- acute myocardial infarction
- coronary artery bypass
- randomized controlled trial
- st elevation myocardial infarction
- antiplatelet therapy
- acute coronary syndrome
- atrial fibrillation
- minimally invasive
- coronary artery
- aortic stenosis
- study protocol
- ultrasound guided
- type diabetes
- blood brain barrier
- subarachnoid hemorrhage
- cerebral ischemia
- meta analyses