Curcumin Mitigates Streptozotocin-Induced Genotoxicity In Vivo by Activating P53 Protein and Inhibiting Oxidative Stress and Chromosomal Aberration.
Alik SahaArnob ChakrovortyBanani BhattacharjeeSisir NandiAsmita SamadderPublished in: Combinatorial chemistry & high throughput screening (2024)
The overall results show that curcumin can reduce chromosomal aberrations and DNA damage by altering the expression of p53 repair proteins. This suggests that curcumin has a promising future as a therapeutic agent, especially when it comes to drug-induced toxicity and the development of novel therapeutics.
Keyphrases
- drug induced
- oxidative stress
- diabetic rats
- liver injury
- dna damage
- copy number
- signaling pathway
- poor prognosis
- induced apoptosis
- ischemia reperfusion injury
- small molecule
- dna repair
- current status
- binding protein
- adverse drug
- high fat diet
- radiation therapy
- radiation induced
- endothelial cells
- high glucose
- protein protein
- dna methylation
- heat shock
- endoplasmic reticulum stress