Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer.
Takahiko MurayamaJun NakayamaXinpei JiangKenichi MiyataAlexander D MorrisKathy Q CaiRahul M PrasadXueying MaAndrey EfimovNeel BelaniEmily R GersteinYin Fei TanYan ZhouJong Wook KimReo MaruyamaKerry S CampbellLu ChenYibin YangSiddharth BalachandranIsrael CañadasPublished in: Cancer discovery (2024)
One promising strategy to trigger an immune response within tumors and enhance immunotherapy efficacy is by inducing endogenous "virus-mimetic" nucleic acid accumulation. Here, we identify DHX9 as a viral-mimicry-inducing factor involved in the suppression of double-stranded RNAs and R-loops and propose DHX9 as a novel target to enhance antitumor immunity. See related commentary by Chiappinelli, p. 389. This article is featured in Selected Articles from This Issue, p. 384.