Iqgap3-Ras axis drives stem cell proliferation in the stomach corpus during homoeostasis and repair.

Junichi MatsuoDaisuke DouchiKhine MyintNaing Naing MonAkihiro YamamuraKazuyoshi KohuDede Liana HengSabirah ChenNur Astiana MawanNapat NuttonmanitYing LiSupriya SrivastavaShamaine Wei Ting HoNicole Yee Shin LeeHong Kai LeeMakoto AdachiAtsushi TamuraJinmiao ChenHenry YangMing TehJimmy Bok-Yan SoWei Peng YongPatrick TanKhay-Guan YeohLinda Shyue Huey ChuangSachiko TsukitaYoshiaki Ito

Published in: Gut (2020)

IQGAP3 is a major regulator of stomach epithelial tissue homoeostasis and repair. The upregulation of IQGAP3 in gastric cancer suggests that IQGAP3 plays an important role in cancer cell proliferation.

Keyphrases

cell proliferation
cell cycle
papillary thyroid
pi k akt
transcription factor
poor prognosis
signaling pathway
squamous cell
squamous cell carcinoma
lymph node metastasis