In vitro evaluation of exocytosis-associated SNARE molecules in human granulosa cells in polycystic ovary syndrome.
Suleyman ErolSelim ZırhGurkan BozdagLale Karakoc SokmensuerSevda Fatma MuftuogluPublished in: Journal of assisted reproduction and genetics (2023)
Exocytosis and vesicular dynamics are among the basic physiological functions of human steroidogenic granulosa cells. Follicle development is necessary for production of competent oocytes and ovulation. Understanding the pathophysiology of PCOS at follicular level is important for disease management. According to our findings, deficits in vesicular dynamics of human granulosa cells in may be central to the treatment strategy for PCOS patients.
Keyphrases
- polycystic ovary syndrome
- induced apoptosis
- insulin resistance
- endothelial cells
- cell cycle arrest
- end stage renal disease
- induced pluripotent stem cells
- pluripotent stem cells
- adipose tissue
- metabolic syndrome
- type diabetes
- newly diagnosed
- peritoneal dialysis
- skeletal muscle
- signaling pathway
- cell proliferation
- combination therapy
- patient reported outcomes