Et 2 Zn-Mediated Gem-Dicarboxylation of Cyclopropanols with CO 2 .
Hongjian LiuLei ShiXiaobin TanBangxiong KangGen LuoHuanfeng JiangChaorong QiPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
An unprecedented Et 2 Zn-mediated gem-dicarboxylation of C─C/C─H single bond of cyclopropanols with CO 2 is disclosed, which provides a straightforward and efficient methodology for the synthesis of a variety of structurally diverse and useful malonic acids in moderate to excellent yields. The protocol features mild reaction conditions, excellent functional group compatibility, broad substrate scope, and facile derivatization of the products. DFT calculations confirm that the transition-metal-free transformation proceeds through a novel ring-opening/α-functionalization/ring-closing/ring-opening/β-functionalization (ROFCOF) process, and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) plays dual important roles in the transformation.
Keyphrases
- density functional theory
- heavy metals
- randomized controlled trial
- ms ms
- molecular dynamics
- high intensity
- molecular dynamics simulations
- simultaneous determination
- quantum dots
- liquid chromatography
- gas chromatography mass spectrometry
- highly efficient
- risk assessment
- mass spectrometry
- gas chromatography
- amino acid
- high resolution
- high resolution mass spectrometry
- solid state