Acquired HIV drug resistance among adults living with HIV receiving first-line antiretroviral therapy in Rwanda: A cross-sectional nationally representative survey.
Gentille MusengimanaElysee TuyishimeAthanase KiromeraSamuel S MalambaAugustin MulindabigwiMadjid R HabimanaCyprien BaribwiraMuhayimpundu RibakareSavio D HabimanaJoshua R DeVosRichard C N MwesigwaEugenie KayirangwaJules M SemuhoreGallican N RwibasiraAmitabh B SutharEric RemeraPublished in: Antiviral therapy (2022)
The prevalence of acquired HIV drug resistance (HIVDR) was high among patient failing to re-suppress VL and was associated with current ART regimen and ever switching ART regimen. The findings of this study support the current WHO guidelines recommending that patients on an NNRTI-based regimen should be switched based on a single viral load test and suggests that national HIV VL monitoring of patients receiving ART has prevented long-term treatment failure that would result in the accumulation of TAMs and potential loss of efficacy of all NRTI used in second-line ART as the backbone in combination with either dolutegravir or boosted PIs.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv infected patients
- hiv aids
- end stage renal disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- hepatitis c virus
- quality improvement
- risk assessment
- cross sectional
- men who have sex with men
- hiv testing
- replacement therapy
- smoking cessation