Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia.
Kaiyuan NiuChengxin ZhangMei YangEithne Margaret MaguireZhenning ShiShasha SunJianping WuChenxin LiuWeiwei AnXinxin WangShan GaoShenglin GeQingzhong XiaoPublished in: Cardiovascular research (2024)
We demonstrate that SNHG18 is a novel regulator in governing VSMC contractile phenotype and preventing injury-induced neointimal hyperplasia. Our findings have important implications for therapeutic targeting snhg18/miR-22-3p signalling in vascular diseases.