A comprehensive expression profile of tRNA-derived fragments in papillary thyroid cancer.

Shiting ShanYuting WangChunfu Zhu

Published in: Journal of clinical laboratory analysis (2020)

In this study, we provided a comprehensive catalog of tRFs involved in PTC and assessed the abnormal expression of these fragments. Through qPCR verification, tRF-39-0VL8K87SIRMM12E2 was found to be the most significantly upregulated tRF. Further tRF and enrichment analysis revealed that tRF-39 was mostly enriched in the "metabolic pathways." These preliminary findings can be used as the basis for further research studies based on the functional role of tRFs in patients with PTC.

Keyphrases

papillary thyroid
lymph node metastasis
poor prognosis
single cell
binding protein
young adults
squamous cell
childhood cancer