Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.
Katsuyuki ShiraiJun-Ichi SaitohAtsushi MushaTakanori AbeDaijiro KobayashiTakeo TakahashiTomoaki TamakiHidemasa KawamuraYukihiro TakayasuMasato ShinoMinoru ToyodaKatsumasa TakahashiJunko HiratoSatoshi YokooKazuaki ChikamatsuTatsuya OhnoTatsuya Nakanonull nullPublished in: Cancer science (2017)
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end-point was the 3-year local control rate, and the secondary end-points included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39 months. Thirty-two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3-year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2-3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon-ion radiotherapy achieved excellent local control and overall survival rates for non-squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.
Keyphrases
- end stage renal disease
- squamous cell carcinoma
- ejection fraction
- newly diagnosed
- chronic kidney disease
- randomized controlled trial
- early stage
- peritoneal dialysis
- systematic review
- clinical trial
- patient reported outcomes
- radiation induced
- mesenchymal stem cells
- locally advanced
- smoking cessation
- ulcerative colitis
- placebo controlled
- double blind
- free survival