SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.

Kyoko KawaharaTomoyuki MukaiMasanori IsekiAkiko NagasuHajime NagasuTakahiko AkagiShoko TsujiSumie Hiramatsu-AsanoYasuyoshi UekiKatsuhiko IshiharaNaoki KashiharaYoshitaka Morita

Published in: International journal of molecular sciences (2021)

SH3BP2 deficiency ameliorated lupus-like manifestations. Modulating SH3BP2 expression could thus provide a novel therapeutic approach to autoimmune diseases.

Keyphrases

systemic lupus erythematosus
disease activity
poor prognosis
signaling pathway
mouse model
rheumatoid arthritis
binding protein