Electroacupuncture Alleviates Inflammation of Dry Eye Diseases by Regulating the α7nAChR/NF-κB Signaling Pathway.
Ning DingQing-Bo WeiWeimin DengXin-Yi SunJie ZhangWei-Ping GaoPublished in: Oxidative medicine and cellular longevity (2021)
These results prove that EA can alleviate DEDs by stimulating the acupoints around the eyes. These beneficial effects are related to the upregulation of α7nAChR and the downregulation of NF-κB in the LG. The protective effect of LG is mediated through the anti-inflammatory pathway mediated by α7nAChR. EA can reduce the NF-κB P65 nuclear transcription and reduce inflammatory factors by regulating α7nAChR. This expression indicates that the α7nAChR/NF-κB signaling pathway may serve as a potential therapeutic target for EA to treat DEDs.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- epithelial mesenchymal transition
- oxidative stress
- lps induced
- poor prognosis
- anti inflammatory
- cell proliferation
- optical coherence tomography
- nuclear factor
- mouse model
- neuropathic pain
- transcription factor
- risk assessment
- immune response
- inflammatory response
- climate change
- binding protein
- cerebral ischemia
- human health
- subarachnoid hemorrhage
- cataract surgery