Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers.
Stefan T G BruijnenN J F VerweijY Y J GentM C HuismanA D WindhorstM KassiouP M van de VenA A LammertsmaO S HoekstraA E VoskuylC J van der LakenPublished in: PloS one (2019)
[11C]DPA-713 and [18F]DPA-714 visualize arthritic joints in active RA patients and most optimal arthritis imaging results were obtained for [11C]DPA-713. Second generation TSPO macrophage PET provides new opportunities for both early diagnosis and therapy monitoring of RA.
Keyphrases
- rheumatoid arthritis
- disease activity
- positron emission tomography
- computed tomography
- ankylosing spondylitis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- pet imaging
- high resolution
- end stage renal disease
- juvenile idiopathic arthritis
- pet ct
- newly diagnosed
- adipose tissue
- interstitial lung disease
- chronic kidney disease
- ejection fraction
- stem cells
- peritoneal dialysis
- prognostic factors
- mass spectrometry
- cell therapy
- mesenchymal stem cells
- drug delivery
- fluorescence imaging
- amino acid