Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma.
Trang T T NguyenEnyuan ShangSalveena SchiffgensConsuelo TorriniChang ShuHasan Orhan AkmanVarun V PrabhuJoshua E AllenMike-Andrew WesthoffGeorg Karpel-MasslerMarkus D SiegelinPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Collectively, these observations suggest that the efficacy of HDAC inhibitors might be significantly enhanced through ClpP activators in model systems of human GBM.