Colorectal cancer-specific IFNβ delivery overcomes dysfunctional dsRNA-mediated type I interferon signaling to increase the abscopal effect of radiotherapy.

Kevin Chih-Yang HuangShu-Fen ChiangHsin-Yu ChangWei-Ze HongJhen-Yu ChenPei-Chih LeeJi-An LiangTao-Wei KeShin-Lei PengAn-Cheng ShiauTsung-Wei ChenPei-Chen YangWilliam Tzu-Liang ChenKun-San Clifford Chao

Published in: Journal for immunotherapy of cancer (2024)

Our results support that increasing cancer-intrinsic IFNβ1 expression is an immunotherapeutic strategy that enhances the RT-induced antitumor immune response in locally patients with advanced CRC with dysfunctional TLR3.

Keyphrases

immune response
dendritic cells
toll like receptor
papillary thyroid
poor prognosis
high glucose
early stage
diabetic rats
squamous cell
radiation therapy
locally advanced
drug induced
squamous cell carcinoma
binding protein
lymph node metastasis
endothelial cells
nuclear factor
long non coding rna