Impact of Free Fatty Acids on Vascular Insulin Responses Across the Arterial Tree: a Randomized Crossover Study.
Kaitlin M LoveLinda A JahnLee M HartlineKevin W AylorZhenqi LiuPublished in: The Journal of clinical endocrinology and metabolism (2023)
Clinically relevant elevation of plasma FFA concentrations induces pan-arterial insulin resistance, the vascular insulin resistance outcomes are interconnected, and insulin-mediated muscle microvascular perfusion associates with cardiovascular disease predictors. Our data provide biologic plausibility whereby a causative relationship between FFAs and cardiovascular disease could exist, and suggest that further attention to interventions which block FFA-mediated vascular insulin resistance may be warranted.
Keyphrases
- insulin resistance
- type diabetes
- cardiovascular disease
- glycemic control
- skeletal muscle
- adipose tissue
- high fat diet
- polycystic ovary syndrome
- metabolic syndrome
- high fat diet induced
- fatty acid
- rheumatoid arthritis
- cardiovascular risk factors
- physical activity
- magnetic resonance
- working memory
- electronic health record
- coronary artery disease
- contrast enhanced
- magnetic resonance imaging
- cardiovascular events
- data analysis