Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment.
Jennifer BorowskyKoichiro HarukiMai Chan LauAndressa Dias CostaJuha P VäyrynenTomotaka UgaiKota ArimaAnnacarolina F L Da SilvaKristen D FeltMelissa ZhaoCarino GurjaoTyler S TwomblyKenji FujiyoshiSara A VäyrynenTsuyoshi HamadaKosuke MimaSusan BullmanTabitha A HarrisonAmanda I PhippsUlrike PetersKimmie NgJeffrey A MeyerhardtMingyang SongEdward L GiovannucciKana WuXuehong ZhangGordon J FreemanCurtis HuttenhowerWendy S GarrettAndrew T ChanBarbara A LeggettVicki L J WhitehallNeal WalkerIan BrownMark BettingtonReiko NishiharaCharles S FuchsJochen K LennerzMarios GiannakisJonathan A NowakShuji OginoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The amount of tissue F. nucleatum is associated with lower density of stromal memory helper T cells. Our findings provide evidence for the interactive pathogenic roles of microbiota and specific immune cells.