Gordon J Freeman

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 60

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

Nature

Clinical cancer research : an official journal of the American Association for Cancer Research

Dana Farber Cancer Institute

Harvard University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Dana Farber Cancer Institute Sep 01 1979

United States

Professor :: Medical Oncology

Education History

Harvard University Sep 01 1974 - Jun 01 1979

United States

PHD :: Microbiology and Molecular Genetics

Publications

Peter Georgiev, SeongJun Han, Amy Y Huang, Thao H Nguyen, Jefte M Drijvers, Hannah Creasey, Joseph A Perry, Cong-Hui Yao, Joon Seok Park, Thomas S Conway, Megan E Fung, Dan Liang, Michael Peluso, Shakchhi Joshi, Jared H Rowe, Brian C Miller, Gordon J Freeman, Arlene H Sharpe, Marcia C Haigis, Alison E Ringel
Age-associated contraction of tumor-specific T cells impairs antitumor immunity. Cancer immunology research (2024)
Amanda L Gill, Peter H Wang, Judong Lee, William H Hudson, Satomi Ando, Koichi Araki, Yinghong Hu, Andreas Wieland, Se Jin Im, Autumn Gavora, Christopher B Medina, Gordon J Freeman, Masao Hashimoto, Steven L Reiner, Rajesh M Valanparambil
PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science immunology 8 (86) (2023)
Joon Seok Park, Francesca S Gazzaniga, Meng Wu, Amalia K Luthens, Jacob Gillis, Wen Zheng, Martin W LaFleur, Sarah B Johnson, Golnaz Morad, Elizabeth M Park, Yifan Zhou, Stephanie S Watowich, Jennifer A Wargo, Gordon J Freeman, Dennis L Kasper, Arlene H Sharpe
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature 617 (7960) (2023)
Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J Freeman, David J Kwiatkowski, Elizabeth P Henske
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Nature communications 14 (1) (2023)
Joon Seok Park, Francesca S Gazzaniga, Meng Wu, Amalia K Luthens, Jacob Gillis, Wen Zheng, Martin W LaFleur, Sarah B Johnson, Golnaz Morad, Elizabeth M Park, Yifan Zhou, Stephanie S Watowich, Jennifer A Wargo, Gordon J Freeman, Dennis L Kasper, Arlene H Sharpe
Publisher Correction: Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Thomas Denize, Opeyemi A Jagede, Sayed Matar, Nourhan El Ahmar, Destiny J West, Emily Walton, Aseman Sheshdeh Bagheri, Varunika Savla, Yasmin Nabil Laimon, Saurabh Gupta, Sai Vikram Vemula, David A Braun, Kelly P Burke, Paul J Catalano, Gordon J Freeman, Robert J Motzer, Michael B Atkins, David F McDermott, Arlene H Sharpe, Toni K Choueiri, Sabina Signoretti
PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J Freeman, David J Kwiatkowski, Elizabeth P Henske
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Nature communications 14 (1) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Joon Seok Park, Francesca S Gazzaniga, Meng Wu, Amalia K Luthens, Jacob Gillis, Wen Zheng, Martin W LaFleur, Sarah B Johnson, Golnaz Morad, Elizabeth M Park, Yifan Zhou, Stephanie S Watowich, Jennifer A Wargo, Gordon J Freeman, Dennis L Kasper, Arlene H Sharpe
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature 617 (7960) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J Freeman, Conghua Xie, Jinfang Zhang
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nature communications 14 (1) (2023)
Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M Asara, Piotr Sicinski, Gordon J Freeman, Wenyi Wei
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity. Nature communications 14 (1) (2023)
Joon Seok Park, Francesca S Gazzaniga, Meng Wu, Amalia K Luthens, Jacob Gillis, Wen Zheng, Martin W LaFleur, Sarah B Johnson, Golnaz Morad, Elizabeth M Park, Yifan Zhou, Stephanie S Watowich, Jennifer A Wargo, Gordon J Freeman, Dennis L Kasper, Arlene H Sharpe
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature (2023)
Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M Asara, Piotr Sicinski, Gordon J Freeman, Wenyi Wei
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity. Nature communications 14 (1) (2023)
Johann S Bergholz Villafane, Qiwei Wang, Qi Wang, Michelle Ramseier, Sanjay Prakadan, Weihua Wang, Rong Fang, Sheheryar K Kabraji, Qian Zhou, G Kenneth Gray, Kayley Abell-Hart, Shaozhen Xie, Xiaocan Guo, Hao Gu, Thanh Von, Tao Jiang, Shuang Tang, Gordon J Freeman, Hye-Jung Kim, Alex K Shalek, Thomas M Roberts, Jean J Zhao
PI3Kβ controls immune evasion in PTEN-deficient breast tumours. Nature (2023)
Jared H Rowe, Ilaria Elia, Osmaan Shahid, Emily F Gaudiano, Natalia E Sifnugel, Sheila Johnson, Amy G Reynolds, Megan E Fung, Shakchhi Joshi, Martin W LaFleur, Joon Seok Park, Kristen E Pauken, Joshua D Rabinowitz, Gordon J Freeman, Marcia C Haigis, Arlene H Sharpe
Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade. Cancer discovery (2023)
Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J Freeman, David J Kwiatkowski, Elizabeth P Henske
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Nature communications 14 (1) (2023)
Joon Seok Park, Francesca S Gazzaniga, Meng Wu, Amalia K Luthens, Jacob Gillis, Wen Zheng, Martin W LaFleur, Sarah B Johnson, Golnaz Morad, Elizabeth M Park, Yifan Zhou, Stephanie S Watowich, Jennifer A Wargo, Gordon J Freeman, Dennis L Kasper, Arlene H Sharpe
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature 617 (7960) (2023)
Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J Freeman, David J Kwiatkowski, Elizabeth P Henske
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Nature communications 14 (1) (2023)
Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J Freeman, Conghua Xie, Jinfang Zhang
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nature communications 14 (1) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Jing Liu, Xia Bu, Chen Chu, Xiaoming Dai, John M Asara, Piotr Sicinski, Gordon J Freeman, Wenyi Wei
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity. Nature communications 14 (1) (2023)
Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J Freeman, Conghua Xie, Jinfang Zhang
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy. Nature communications 14 (1) (2023)
Meenal Datta, Sampurna Chatterjee, Elizabeth M Perez, Simon Gritsch, Sylvie Roberge, Mark Duquette, Ivy X Chen, Kamila Naxerova, Ashwin Srinivasan Kumar, Mitrajit Ghosh, Kyrre E Emblem, Mei R Ng, William W Ho, Pragya Kumar, Shanmugarajan Krishnan, Xinyue Dong, Maria C Speranza, Martha R Neagu, J Bryan Iorgulescu, Raymond Y Huang, Gilbert Youssef, David A Reardon, Arlene H Sharpe, Gordon J Freeman, Mario L Suvà, Lei Xu, Rakesh K Jain
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (6) (2023)
Thomas Denize, Yue Hou, Jean-Christophe Pignon, Emily Walton, Destiny J West, Gordon J Freeman, David A Braun, Catherine J Wu, Saurabh Gupta, Robert J Motzer, Michael B Atkins, David McDermott, Toni K Choueiri, Sachet A Shukla, Sabina Signoretti
Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (18) (2022)
Kathleen M Mahoney, Petra Ross-MacDonald, Long Yuan, Linan Song, Eliseo Veras, Megan Wind-Rotolo, David F McDermott, Frank Stephen Hodi, Toni K Choueiri, Gordon J Freeman
Soluble PD-L1 as an early marker of progressive disease on nivolumab. Journal for immunotherapy of cancer 10 (2) (2022)
Masao Hashimoto, Koichi Araki, Maria Andrea Cardenas, Peng Li, Rohit R Jadhav, Haydn T Kissick, William H Hudson, Donald J McGuire, Rebecca C Obeng, Andreas Wieland, Judong Lee, Daniel T McManus, James L Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E West, Christopher D Scharer, Gordon J Freeman, Arlene H Sharpe, Suresh R Ramalingam, Alex Pellerin, Volker Teichgräber, William J Greenleaf, Christiane Neumann, Jorg J Goronzy, Pablo Umaña, Warren J Leonard, Kendall A Smith, Rajesh M Valanparambil
PD-1 combination therapy with IL-2 modifies CD8 + T cell exhaustion program. Nature 610 (7930) (2022)
Wenjun Xiong, Xueliang Gao, Tiantian Zhang, Baishan Jiang, Ming-Ming Hu, Xia Bu, Yang Gao, Lin-Zhou Zhang, Bo-Lin Xiao, Chuan He, Yishuang Sun, Haiou Li, Jie Shi, Xiangling Xiao, Bolin Xiang, Conghua Xie, Gang Chen, Haojian Zhang, Wenyi Wei, Gordon J Freeman, Hong-Bing Shu, Haizhen Wang, Jinfang Zhang
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy. Nature communications 13 (1) (2022)
Qingyuan Huang, Fei Li, Hai Hu, Zhaoyuan Fang, Zhendong Gao, Guozhan Xia, Billy Wai-Lung Ng, Alireza Khodadadi-Jamayran, Ting Chen, Jiehui Deng, Hua Zhang, Christina Almonte, Kristen E Labbe, Han Han, Ke Geng, Sittinon Tang, Gordon J Freeman, Yuan Li, Haiquan Chen, Kwok-Kin Wong
Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non-small cell lung cancer. Science advances 8 (5) (2022)
James A Torchia, Alexander H Tavares, Laura S Carstensen, Da-Yuan Chen, Jessie Huang, Tianshu Xiao, Sonia Mukherjee, Patrick M Reeves, Hua Tu, Ann E Sluder, Bing Chen, Darrell N Kotton, Richard A Bowen, Mohsan Saeed, Mark C Poznansky, Gordon J Freeman
Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo. Science advances 8 (49) (2022)
Keith D Kauffman, Daniel L Barber, Nickiana E Lora, Sivaranjani Namasivayam, Paul J Baker, Olena Kamenyeva, Taylor W Foreman, Christine E Nelson, Deivide Oliveira-de-Souza, Caian L Vinhaes, Ziv Rafael Yaniv, Cecilia S Lindestam Arlehamn, Alessandro Sette, Gordon J Freeman, Rashida Moore, null null, Alan Sher, Katrin D Mayer-Barber, Bruno Bezerril Andrade, Juraj Kabat, Laura E Via
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Science immunology 6 (55) (2022)
Vijayakumar Velu, Kehmia Titanji, Hasan Ahmed, Ravi Dyavar Shetty, Lakshmi S Chennareddi, Gordon J Freeman, Rafi Ahmed, Rama Rao Amara
PD-1 blockade following ART interruption enhances control of pathogenic SIV in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America 119 (33) (2022)
Carlos R Gil Del Alcazar, Anne Trinh, Maša Alečković, Ernesto Arturo Rojas-Jiménez, Nicholas W Harper, Michael U J Oliphant, Shanshan Xie, Ethan D Krop, Bethlehem A Lulseged, Katherine C Murphy, Tanya E Keenan, Eliezer Van Allen, Sara M Tolaney, Gordon J Freeman, Deborah A Dillon, Senthil K Muthuswamy, Kornelia Polyak
Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer. Cancer immunology research 10 (6) (2022)
Shengqing Stan Gu, Wubing Zhang, Xiaoqing Wang, Peng Jiang, Nicole Traugh, Ziyi Li, Clifford Meyer, Blair Stewig, Yingtian Xie, Xia Bu, Michael P Manos, Alba Font-Tello, Evisa Gjini, Ana Lako, Klothilda Lim, Jake Conway, Alok K Tewari, Zexian Zeng, Avinash Das Sahu, Collin Tokheim, Jason L Weirather, Jingxin Fu, Yi Zhang, Benjamin Kroger, Jin Hua Liang, Paloma Cejas, Gordon J Freeman, Scott Rodig, Henry W Long, Benjamin E Gewurz, F Stephen Hodi, Myles Brown, X Shirley Liu
Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade. Cancer discovery 11 (6) (2021)
Jennifer A Lo, Masayoshi Kawakubo, Vikram R Juneja, Mack Y Su, Tal H Erlich, Martin W LaFleur, Lajos Vince Kemény, Mamunur Rashid, Mohsen Malehmir, S Alireza Rabi, Rumya Raghavan, Jennifer Allouche, Gyulnara Kasumova, Dennie T Frederick, Kristen E Pauken, Qing Yu Weng, Marcelo Pereira da Silva, Yu Xu, Anita A J van der Sande, Whitney Silkworth, Elisabeth Roider, Edward P Browne, David J Lieb, Belinda Wang, Levi A Garraway, Catherine J Wu, Keith T Flaherty, Constance E Brinckerhoff, David W Mullins, David J Adams, Nir Hacohen, Mai P Hoang, Genevieve Marie Boland, Gordon J Freeman, Arlene H Sharpe, Dieter Manstein, David E Fisher
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. Science translational medicine 13 (581) (2021)
Xia Bu, Vikram R Juneja, Carol G Reynolds, Kathleen M Mahoney, Melissa T Bu, Kathleen A McGuire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R Klein, Edward A Greenfield, Philippe Armand, Jerome Ritz, Arlene H Sharpe, Gordon J Freeman
Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses. Cancer immunology research 9 (12) (2021)
Sheikh Abdul Rahman, Bhrugu Yagnik, Alexander P R Bally, Kristen N Morrow, Shelly Wang, Thomas H Vanderford, Gordon J Freeman, Rajesh M Valanparambil, Rama Rao Amara
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8+ T cells in lymphoid tissue. Science immunology 6 (63) (2021)
Jennifer Borowsky, Koichiro Haruki, Mai Chan Lau, Andressa Dias Costa, Juha P Väyrynen, Tomotaka Ugai, Kota Arima, Annacarolina F L Da Silva, Kristen D Felt, Melissa Zhao, Carino Gurjao, Tyler S Twombly, Kenji Fujiyoshi, Sara A Väyrynen, Tsuyoshi Hamada, Kosuke Mima, Susan Bullman, Tabitha A Harrison, Amanda I Phipps, Ulrike Peters, Kimmie Ng, Jeffrey A Meyerhardt, Mingyang Song, Edward L Giovannucci, Kana Wu, Xuehong Zhang, Gordon J Freeman, Curtis Huttenhower, Wendy S Garrett, Andrew T Chan, Barbara A Leggett, Vicki L J Whitehall, Neal Walker, Ian Brown, Mark Bettington, Reiko Nishihara, Charles S Fuchs, Jochen K Lennerz, Marios Giannakis, Jonathan A Nowak, Shuji Ogino
Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (10) (2021)
Dhouha Daassi, Kathleen M Mahoney, Gordon J Freeman
The importance of exosomal PDL1 in tumour immune evasion. Nature reviews. Immunology 20 (4) (2020)
J Bryan Iorgulescu, Prafulla C Gokhale, Maria C Speranza, Benjamin K Eschle, Michael J Poitras, Margaret K Wilkens, Kara M Soroko, Chhayheng Chhoeu, Aine Knott, Yan Gao, Mary Jane Lim-Fat, Gregory J Baker, Dennis M Bonal, Quang-Dé Nguyen, Gareth R L Grant, Keith L Ligon, Peter Karl Sorger, E Antonio Chiocca, Ana C Anderson, Paul T Kirschmeier, Arlene H Sharpe, Gordon J Freeman, David A Reardon
Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (1) (2020)
Miriam Ficial, Opeyemi A Jagede, Miriam Sant'Angelo, Yue Hou, Abdallah Flaifel, Jean-Christophe Pignon, David A Braun, Megan Wind-Rotolo, Maura A Sticco-Ivins, Paul J Catalano, Gordon J Freeman, Arlene H Sharpe, F Stephen Hodi, Robert J Motzer, Catherine J Wu, Michael B Atkins, David F McDermott, Sachet A Shukla, Toni K Choueiri, Sabina Signoretti
Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (5) (2020)
Rupal S Bhatt, Abdulla Berjis, Julie C Konge, Kathleen M Mahoney, Alyssa N Klee, Samuel S Freeman, Chun-Hau Chen, Opeyemi A Jagede, Paul J Catalano, Jean-Christophe Pignon, Maura Sticco-Ivins, Baogong Zhu, Ping Hua, Jo Soden, Jie Zhu, David F McDermott, Antonio R Arulanandam, Sabina Signoretti, Gordon J Freeman
KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1. Cancer immunology research 9 (2) (2020)
Nikolaos Patsoukis, Jonathan S Duke-Cohan, Apoorvi Chaudhri, Halil-Ibrahim Aksoylar, Qi Wang, Asia Council, Anders Berg, Gordon J Freeman, Vassiliki A Boussiotis
Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Communications biology 3 (1) (2020)
Jaymin M Patel, Andrew Goss, Judy E Garber, Vanda Torous, Edward T Richardson, Miriam J Haviland, Michele R Hacker, Gordon J Freeman, Tessa Nalven, Brian Alexander, Larissa Lee, Laura C Collins, Stuart J Schnitt, Nadine Tung
Retinoblastoma protein expression and its predictors in triple-negative breast cancer. NPJ breast cancer 6 (2020)
Yang Gao, Naoe Taira Nihira, Xia Bu, Chen Chu, Jinfang Zhang, Aleksandra Kolodziejczyk, Yizeng Fan, Ngai Ting Chan, Leina Ma, Jing Liu, Dong Wang, Xiaoming Dai, Huadong Liu, Masaya Ono, Akira Nakanishi, Hiroyuki Inuzuka, Brian J North, Yu-Han Huang, Samanta Sharma, Yan Geng, Wei Xu, X Shirley Liu, Lei Li, Yoshio Miki, Piotr Sicinski, Gordon J Freeman, Wenyi Wei
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nature cell biology 22 (9) (2020)
Kathleen M Mahoney, Gordon J Freeman
Acidity changes immunology: a new VISTA pathway. Nature immunology 21 (1) (2020)
David A Braun, Yue Hou, Ziad Bakouny, Miriam Ficial, Miriam Sant' Angelo, Juliet Forman, Petra Ross-Macdonald, Ashton C Berger, Opeyemi A Jegede, Liudmilla Elagina, John Steinharter, Maxine Sun, Megan Wind-Rotolo, Jean-Christophe Pignon, Andrew D Cherniack, Lee Lichtenstein, Donna S Neuberg, Paul Catalano, Gordon J Freeman, Arlene H Sharpe, David F McDermott, Eliezer Van Allen, Sabina Signoretti, Catherine J Wu, Sachet A Shukla, Toni K Choueiri
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma. Nature medicine 26 (6) (2020)
Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet A Shukla, Dominick Bosse, Aly-Khan A Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F McDermott, Gordon J Freeman, Eliezer Van Allen, Stuart L Schreiber, F Stephen Hodi, William R Sellers, Levi A Garraway, Andrew T Chan, Toni K Choueiri, Marios Giannakis
Metabolomic adaptations and correlates of survival to immune checkpoint blockade. Nature communications 10 (1) (2019)
Kathleen M Mahoney, Sachet A Shukla, Nikolaos Patsoukis, Apoorvi Chaudhri, Edward P Browne, Arnon Arazi, Thomas M Eisenhaure, William F Pendergraft, Ping Hua, Hung C Pham, Xia Bu, Baogong Zhu, Nir Hacohen, Edward F Fritsch, Vassiliki A Boussiotis, Catherine J Wu, Gordon J Freeman
A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer immunology, immunotherapy : CII 68 (3) (2018)
Filippos Porichis, Meghan G Hart, Alexandra Massa, Holly L Everett, Antigoni Morou, Jonathan Richard, Nathalie Brassard, Maxime Veillette, Muska Hassan, Ngoc Le Ly, Jean-Pierre Routy, Gordon J Freeman, Mathieu Dubé, Andrés Finzi, Daniel E Kaufmann
Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells. Journal of immunology (Baltimore, Md. : 1950) 201 (3) (2018)
Catherine L Tan, Michael J Peluso, Jefte M Drijvers, Camila M Mera, Shannon M Grande, Keturah E Brown, Jernej Godec, Gordon J Freeman, Arlene H Sharpe
CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes. ImmunoHorizons 2 (7) (2018)
Sean Philip Arlauckas, Christopher S Garris, Rainer H Kohler, Maya Kitaoka, Michael F Cuccarese, Katherine S Yang, Miles A Miller, Jonathan C Carlson, Gordon J Freeman, Robert M Anthony, Ralph Weissleder, Mikaël J Pittet
In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Science translational medicine 9 (389) (2018)
Franz L Ricklefs, Quazim A Alayo, Harald Krenzlin, Ahmad B Mahmoud, Maria C Speranza, Hiroshi Nakashima, Josie L Hayes, Kyungheon Lee, Leonora Balaj, Carmela Passaro, Arun K Rooj, Susanne Krasemann, Bob S Carter, Clark C Chen, Tyler Steed, Jeffrey Treiber, Scott J Rodig, Katherine S Yang, Ichiro Nakano, Hakho Lee, Ralph Weissleder, Xandra O Breakefield, Jakub Godlewski, Manfred Westphal, Katrin Lamszus, Gordon J Freeman, Agnieszka Bronisz, Sean E Lawler, E Antonio Chiocca
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Science advances 4 (3) (2018)
Peter T Sage, Frank Alexander Schildberg, Raymond A Sobel, Vijay K Kuchroo, Gordon J Freeman, Arlene H Sharpe
Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. Journal of immunology (Baltimore, Md. : 1950) 200 (8) (2018)
Vikram R Juneja, Kathleen A McGuire, Robert T Manguso, Martin W LaFleur, Natalie B Collins, W Nicholas Haining, Gordon J Freeman, Arlene H Sharpe
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. The Journal of experimental medicine 214 (4) (2017)
Alice Oliffson Kamphorst, Andreas Wieland, Tahseen H Nasti, Shu Yang, Ruan Zhang, Daniel L Barber, Bogumila T Konieczny, Candace Z Daugherty, Lydia Koenig, Ke Yu, Gabriel L Sica, Arlene H Sharpe, Gordon J Freeman, Bruce R Blazar, Laurence A Turka, Taofeek K Owonikoko, Rathi N Pillai, Suresh S Ramalingam, Koichi Araki, Rajesh M Valanparambil
Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.) 355 (6332) (2017)

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Gordon J Freeman