Graft-versus-leukaemia immunity is retained following treatment with post-transplant cyclophosphamide alone or combined with tocilizumab in humanised mice.
Chloe SligarEllie ReillyPeter CuthbertsonKara Lea VineKatrina M BirdAmal ElhageStephen I AlexanderRonald SluyterDebbie WatsonPublished in: Clinical & translational immunology (2024)
Collectively, this research demonstrates that PTCy alone or combined with TOC impairs GVHD without compromising GVL immunity.