microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2.
Jimin MinTae-Su HanYoojin SohnTakahiro ShimizuBoram ChoiSeong-Woo BaeKeun HurSeong-Ho KongYun-Suhk SuhHyuk-Joon LeeJang-Seong KimJeong-Ki MinWoo-Ho KimV Narry KimEunyoung ChoiJames R GoldenringHan-Kwang YangPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)
We found down-regulation of miR-30a in preneoplastic lesions and its tumor-suppressive functions by targeting ITGA2 in GC. The level of ITGA2, which functions as an oncogene, was up-regulated in human GC. The results of this study suggest that coordination of the miR-30a-ITGA2 axis may serve as an important mechanism in the development of gastric precancerous lesions and intestinal-type GC.