The microRNA miR-33 is a pleiotropic regulator of metabolic and developmental processes in Drosophila melanogaster.
Laure-Alix ClerbauxHayley SchultzSamara Roman-HolbaDan Fu RuanRonald YuAbigail M LambGuido T BommerJennifer A KennellPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
Our data suggest that miR-33 is a conserved regulator of lipid homeostasis, and its targets are involved in both degradation and synthesis of fatty acids and TAG. The constellation of phenotypes involving tissues that are highly sensitive to metabolic state suggests that miR-33 serves to prevent extreme fluctuations in metabolically sensitive tissues.