Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.
Yong Nie ZeYu HuangJing ChenBoLei LiBenhua ZengChing-Heng ChouXin ZhengJingWei XieHao LiYu HaoGuo ChenFuXing PeiBin ShenVirginia B KrausHong WeiXuedong ZhouLei ChengPublished in: Annals of the rheumatic diseases (2020)
The study clearly establishes a direct gut microbiome-OA connection that sets the stage for a new means of exploring OA pathogenesis and potentially new OA therapeutics. Alterations of Fusobacterium, Faecalibaterium and Ruminococcaceae suggest a role of these particular microbes in exacerbating OA.