Recombinant Treponema pallidum protein Tp47 induces angiogenesis by modulating the matrix metalloproteinase/tissue inhibitor of metalloproteinase balance in endothelial cells.

Z-X GaoX LuoL-L LiuL-R LinM-L TongTian-Ci Yang

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2019)

The results reveal the underlying mechanism of angiogenesis promoted by Tp47, namely, upregulating MMP-1 and MMP-10 expression to disrupt the MMP/TIMP balance through the Akt/mTOR/S6 pathway. These findings contribute to our understanding of the pathophysiology of syphilis.

Keyphrases

endothelial cells
vascular endothelial growth factor
cell migration
signaling pathway
cell proliferation
high glucose
poor prognosis
binding protein
human immunodeficiency virus
single cell
genome wide
small molecule
protein protein
gene expression
hepatitis c virus
cell free