Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome Disorders-A Review of In Vivo Studies.
Ewelina GumbarewiczAgata JarząbAndrzej StepulakWirginia Kukuła-KochPublished in: International journal of molecular sciences (2022)
Inflammation is a protective reaction of the innate immune system as a response to imbalances caused by a specific stimulus, a disease or a pathogen. A prolonged inflammatory condition may lead to the development of metabolic syndrome, which affects more than one-fourth of the world's population. This condition leads to the development of multi-organ disorders based on disrupted blood lipid and sugar levels, hypertension and oxidative stress. The review aims to present Zingiber officinale Rosc. as a plant that exhibits a variety of healing properties and restores the organism's equilibrium. Ginger (GI) rhizomes have been commonly used in traditional medicine to treat arthritis, stomach ache, nonalcoholic fatty liver disease, rheumatism, nervous system syndromes, asthma, diabetes and nausea caused by pregnancy or chemotherapy. This review gathers together data from in vivo experiments related to the application of ginger for the treatment of inflammatory conditions, obesity, diabetes and other related disorders as a consequence of metabolic syndrome, including the confirmed molecular mechanisms of action.
Keyphrases
- metabolic syndrome
- oxidative stress
- type diabetes
- insulin resistance
- cardiovascular disease
- uric acid
- blood pressure
- immune response
- glycemic control
- chronic obstructive pulmonary disease
- dna damage
- machine learning
- diabetic rats
- weight loss
- induced apoptosis
- body mass index
- adipose tissue
- radiation therapy
- electronic health record
- preterm birth
- pregnant women
- fatty acid
- lung function
- replacement therapy
- signaling pathway
- drug induced
- air pollution
- heat shock protein
- locally advanced
- plant growth