Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2-Bl/HLA-G.
Mayumi IshikawaAndrew J BrooksManuel A Fernández-RojoJohan MedinaYash ChhabraShiro MinamiKathryn A TunnyRobert G PartonJulian P VivianJamie RossjohnViral ChikaniGrant A RammKen K Y HoMichael J WatersPublished in: Hepatology (Baltimore, Md.) (2020)
GH induction of H2-Bl expression is crucial for reducing innate immune-mediated apoptosis and promoting survival after PHx in C57BL/6 mice. Treatment with HLA-G may lead to improved clinical outcomes following liver surgery or transplantation.