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Do Liquid Nitrogen-treated Tumor-bearing Nerve Grafts Have the Capacity to Regenerate, and Do They Pose a Risk of Local Recurrence? A Study in Rats.

Hirotaka YonezawaNorio YamamotoKatsuhiro HayashiAkihiko TakeuchiShinji MiwaKentaro IgarashiSei MorinagaYohei AsanoShiro SaitoKaoru TadaTakayuki NojimaHiroyuki Tsuchiya
Published in: Clinical orthopaedics and related research (2022)
A frozen nerve autograft has a similar regenerative potential to that of a nerve autograft. Although the findings in a rat model do not guarantee efficacy in humans, if they are substantiated by large-animal models, clinical trials will be needed to evaluate the efficacy of tumor-bearing frozen nerve grafts in humans.
Keyphrases
  • clinical trial
  • peripheral nerve
  • stem cells
  • mesenchymal stem cells
  • randomized controlled trial
  • anterior cruciate ligament reconstruction
  • open label
  • free survival