A Secretory Vesicle Failure in Parkinson's Disease Occurs in Human Platelets.
Pablo MontenegroMercedes PueyoJesús Norelis LorenzoMaría Dolores Villar-MartínezAntonio AlayónFrancisco CarrilloRicardo BorgesPublished in: Annals of neurology (2022)
These findings indicate a functional impairment in the handling of amines by SVs in PD patients. This defect may serve as a biomarker of PD, and the approach described here may be potentially used for the subclinical detection of PD and to establish a platform to assay disease modifying drugs. ANN NEUROL 2022.